Scientific articles about treating arthritis with stem cells
Barbara,
I am happy to quote articles on arthritis and stem cell therapy. The top line is the link, just copy and paste into your browser. The secondline is a brief description of the article so the reader does not waste time reading an article he is not interested in. The third line is the title of the article and the last line is the Journal in which it was published. Please note that these are all highly reputable scientific journals.
http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-CT-1300[/B]_Michalek_et_al
This is a large study of 1114 osteoarthritis patients who had adipose-derived autologous stem cells treatment to 1856 joints, mostly hips and knees. Follow up was 12.1 – 54.3 months. No side effects, systemic infection or cancer was noted. Most patients improved 3 – 12 months after treatment with an overall 91% of patients improving.
Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis
Cell Transplantation Appeared or available online: January 20, 2015
http://ajs.sagepub.com/content/42/3/648.short
MSCs were transplanted into a group of 25 active patients with chondral defects of the knee and followed for 3 years. All patients showed significant improvement.
One-Step Surgery With Multipotent Stem Cells for the Treatment of Large Full-Thickness Chondral Defects of the Knee
American Journal of Sports Medicine March 2014 vol. 42 no. 3 648-657
http://www.medicaldaily.com/stem-cells-fat-cells-can-repair-cartilage-ease-arthritis-pain-242141
Pre-treatment of the stem cells derived from fat cells can encourage growth of cartilage cells, a finding that could help ease pain in people suffering from a common type of arthritis.
Stem Cells of Fat Cells Can Repair Cartilage, Ease Arthritis Pain
.Published in Stem Cell & Research Therapy
http://www.ncbi.nlm.nih.gov/pubmed/25998005
This article describes how MSCs interact with endothelial cells to become bone.
Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling
Stem Cell Research & Therapy 2015, 6:88 doi:10.1186/s13287-015-0065-6
http://news.emory.edu/stories/2013/03/ortho_mautner_stem_cell_injections_osteo/index.html
Emory University website with a video showing patients treated for arthritis.
Stem cell injections may relieve arthritis pain
http://www.arthritis-research.com/content/17/1/113
This is a review article about treating arthritis with stem cells.
Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
Arthritis Research & Therapy 2015, 17:113 doi:10.1186/s13075-015-0634-1
http://www.arthritis-research.com/content/15/2/112
This is a rabbit study which shows the efficacy of stem cell therapy in osteoarthritis.
Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?
Arthritis Research & Therapy 2013, 15:112 doi:10.1186/ar4190
http://www.ncbi.nlm.nih.gov/pubmed/18477997
This is a review article which speculates on future strategies in developing protocols for stem cells in arthritis.
Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy
Rheumatology (2008) 4, 371-380 doi:10.1038/ncprheum0816
Received 12 December 2007 | Accepted 3 March 2008 | Published online: 13 May 2008
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178263/
This article reviews the literature concerning chondrogenesis – growing new cartilage in the knee with stem cells.
Stem cell application for osteoarthritis in the knee joint: A minireview
World Journal of Stem Cells. 2014 Nov 26; 6(5): 629–636.
Published online 2014 Nov 26. doi: 10.4252/wjsc.v6.i5.629 PMCID: PMC4178263
http://www.healio.com/orthopedics/biologics/news/online/{cee4e71a-50c2-4190-bf72-590446b3cade}/stem-cell-based-therapy-found-safe-and-efficacious-for-distal-tibia-fractures
This is an efficacy study with 12 patients (intervention group) who were treated compared to 12 patients (control group) who were not treated with stem cell therapy. At 12 months follow-up there were 3 non-unions in the control group. The intervention group all healed without complication.
Stem cell-based therapy found safe and efficacious for distal tibia fractures
Molecular Therapy (2013); 21 8, 1631–1638. doi:10.1038/mt.2013.109
http://www.ncbi.nlm.nih.gov/pubmed/11884830
This is an early study showing that stem cells exist in fat.
Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells.
Plastic & Reconstructive Surgery 2002; 109 (3): 1033.
http://www.ncbi.nlm.nih.gov/pubmed/13678450
This early efficacy study also compares MSCs from bone marrow and fat and concludes that fat has more cells.
Cell-Based Therapy in Repair of osteochondral Defects: A Novel Use for Adipose Tissue
Tissue Engineering Vol 9 No 4, 2003
http://www.ncbi.nlm.nih.gov/pubmed/26239757
This is a lab study designed to show that stem cells can repair intervetebral discs.
An in vitro investigation into the role of bone marrow derived mesenchymal stem cells in the control of disc degeneration.
Molecular Medicine Reports. 2015 Jul 29;PMID: 26239757 [PubMed - as supplied by publisher]