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Thread: Resveratrol Protects Against Cancer

  1. #1
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    Default Resveratrol Protects Against Cancer

    Science Blog
    October 3, 2018

    Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed.

    A team of scientists from the University of Geneva (UNIGE), Switzerland, studied a well-known natural product, resveratrol, which is found in grapes and in red wine. While its chemopreventive properties against cancers affecting the digestive tract have been documented by previous studies, resveratrol has so far shown no effect on lung cancers. Thanks to nasal administration, the UNIGE team obtained very promising results in a study conducted in mice and described in the journal Scientific Reports.

    “We tried to prevent lung cancer induced by a carcinogen found in cigarette smoke by using resveratrol, an already well-documented molecule, in a mouse model,” explains Muriel Cuendet, Associate Professor in the School of pharmaceutical sciences of the UNIGE Faculty of Science. This 26 week long study contained four groups of mice. The first one, the control, received neither carcinogen nor resveratrol treatment. The second received only the carcinogen, the third received both the carcinogen and the treatment, and the fourth received only the treatment. “We observed a 45% decrease in tumor load per mouse in the treated mice. They developed fewer tumors and of smaller size than untreated mice,” says Muriel Cuendet. When comparing the two groups that were not exposed to carcinogen, 63% of the mice treated did not develop cancer, compared to only 12.5% of the untreated mice. “Resveratrol could therefore play a preventive role against lung cancer,” she continues.

    This formulation is applicable to humans

    However, resveratrol does not seem suitable for preventing lung cancer: when ingested, it is metabolized and eliminated within minutes, and therefore does not have time to reach the lungs. “This is why our challenge was to find a formulation in which resveratrol could be solubilized in large quantities, even though it is poorly soluble in water, in order to allow nasal administration. This formulation, applicable to humans, allows the compound to reach the lungs,” explains Aymeric Monteillier, a scientist in the School of pharmaceutical sciences of the UNIGE Faculty of Science, and the first author of the study. The resveratrol concentration obtained in the lungs after nasal administration of the formulation was 22 times higher than when taken orally. The chemoprevention mechanism is probably related to apoptosis, a process by which cells program their own death and from which cancer cells escape. The UNIGE research team will now focus on finding a biomarker that could contribute to the selection of people eligible for preventive treatment with resveratrol.

    Towards a preventive treatment?

    Resveratrol is an already well-known molecule, which is found in food supplements, meaning that no further toxicological study would be needed prior to commercialisation as a preventive treatment. “This discovery is unfortunately of little economic interest to pharmaceutical groups. The molecule is indeed simple and non-patentable and cancer prevention studies require a follow-up over many years,” regrets Muriel Cuendet, without excluding the development of preventive treatment in humans.
    First treatment in 2007. Pioneering ever since.

    Barbara

  2. #2

    Default

    this is interesting, just 2 days ago a medical blurb on TV come out and said the truth of drinking wine is that doing it regularly is a cause
    of cancer.
    https://www.independent.co.uk/life-s...-a7570526.html

  3. #3
    Join Date
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    western pa near pittsburgh
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    Default Copd, cancer and heart disease

    Barb; It seems lung cancer and heart disease seem to be a bonus of COPD? From what I have read COPD medicines cause calcification of arteries, there is only one way to break up this calcium. It would be good for COPD patients to read Knapen study on mk-7 and www.ncbi.nlm.nih.gov/pubmed/29132356, this shows that after 3years of vitamin mk-7 will break up this calcium.God bless

  4. #4
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    Default

    Quote Originally Posted by willis View Post
    this is interesting, just 2 days ago a medical blurb on TV come out and said the truth of drinking wine is that doing it regularly is a cause
    of cancer.
    https://www.independent.co.uk/life-s...-a7570526.html
    And then there are the studies that say that a drink a day is heart healthy! Often a bias can be found if you look at who funded the study, but many times it doesn't seem like there is a special interest. Enjoy in moderation is how I feel about it.
    First treatment in 2007. Pioneering ever since.

    Barbara

  5. #5
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    Default

    Quote Originally Posted by jgp View Post
    Barb; It seems lung cancer and heart disease seem to be a bonus of COPD? From what I have read COPD medicines cause calcification of arteries, there is only one way to break up this calcium. It would be good for COPD patients to read Knapen study on mk-7 and www.ncbi.nlm.nih.gov/pubmed/29132356, this shows that after 3years of vitamin mk-7 will break up this calcium.God bless
    Thanks for this jgp. I found a supplement that has MK4 (you provided info on this in another post) and MK7. The cost of such supplements is quite reasonable. I'm not sure why the NIH study feels that more studies are needed, but that is the nature of research I guess. Unless there would be some reason one's doctor said not to supplement with K, I see no harm in starting such a regimen (including Vitamin D3) now rather than waiting for more studies.
    First treatment in 2007. Pioneering ever since.

    Barbara

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