View Full Version : 1st Artificial Windpipe Made With Stem Cells Seems Successful

11-25-2011, 08:49 PM
1st Artificial Windpipe Made With Stem Cells Seems Successful
Last Updated: November 23, 2011.

Using patient's own cells to create custom airway cut risk for transplant rejection, scientists say.


WEDNESDAY, Nov. 23 (HealthDay News) -- A 36-year-old husband and father of two children with an inoperable tumor in his trachea (windpipe) has received the world's first artificial trachea made with stem cells.

A report published online Nov. 23 in The Lancet described the transplant surgery, which was performed in June at the Karolinska University Hospital in Stockholm, Sweden.

Without the transplant, the authors of the report explained, the man from Reykjavik, Iceland would have died. A golf ball-sized tumor on his trachea had begun to restrict his breathing. In a 12-hour procedure, doctors completely removed the affected area of his trachea and replaced it with an artificial one.

The artificial trachea was custom-made using three-dimensional imaging. First, a glass model was built to help shape an artificial scaffold. Stem cells were then inserted into the scaffold to create a functioning airway, the authors explained in a journal news release.

The scientists said their technique is an improvement over other methods because they used the patient's own cells to create the airway so there is no risk of rejection and the patient does not have to take immunosuppressive drugs.

In addition, they noted, because the trachea was custom-made it would be an ideal fit for the patient's body size and shape, and would eliminate the need to remain on a waiting list for a human donor.

"The patient has been doing great for the last four months and has been able to live a normal life. After arriving in Iceland at the start of July, he was one month in hospital and another month in a rehabilitation center," a co-author of the study and the physician who referred the patient for the procedure, Tomas Gudbjartsson, of Landspitali University Hospital and University of Iceland, Reykjavik, said in the news release.

The transplant team has since performed another transplant on a second patient from Maryland with cancer of the airway. This patient's bioartificial scaffold, however, was made from nanofibers. They now hope to treat a 13-month-old South Korean infant also using this method.

"We will continue to improve the regenerative medicine approaches for transplanting the windpipe and extend it to the lungs, heart and esophagus. And investigate whether cell therapy could be applied to irreversible diseases of the major airways and lungs," said Gudbjartsson.

Although the technique shows promise, Dr. Harald C. Ott and Dr. Douglas J. Mathisen, from Massachusetts General Hospital and Harvard Medical School in Boston, cautioned that more research must to be done to fully evaluate its safety and effectiveness.

"To be adjudged successful, bioartificial organs must function over a long time -- short-term clinical function is an important achievement, but is only one measure of success. Choice of ideal scaffold material, optimum cell source, well-defined tissue culture conditions, and perioperative management pose several questions to be answered before the line to broader clinical application of any bioartificial graft can be crossed safely and confidently," Ott and Mathisen concluded in the news release.

More information

The U.S. National Institutes of Health has more about stem cells.

SOURCE: The Lancet, news release, Nov. 23, 2011

12-02-2011, 05:51 PM
It's interesting how this company got started. Read the last paragraph.

Cell culture startup’s scaffold used in 2nd-ever synthetic trachea transplant

A two-year-old Ohio State University spinoff’s nanofiber scaffold was used to grow a patient’s own stem cells and then implanted into the patient after his trachea was removed — in an operation that’s being billed as the world’s second successful synthetic trachea transplant.

Columbus-based Nanofiber Solutions designed and built the scaffold used in the procedure. The company’s cell culture products use polymer nanofibers to more accurately simulate the 3-D structure of human tissue.

The synthetic trachea was grown on the scaffold in a bioreactor for two days before being transplanted into the patient, according to a statement from Harvard Bioscience, which made the bioreactor.

The surgery was performed in Stockholm, Sweden. While the operation was the second successful trachea transplant, it is the first procedure on a U.S. patient and with a U.S.-made scaffold, according to the statement.

Nanofiber Solutions was born from an entry in a business plan competition written by co-founder and then-doctoral student Jed Johnson, who was studying materials science engineering. After winning the contest and $90,000 in cash and in-kind services, Johnson teamed up with an Ohio State materials science engineering professor to begin the company.


12-02-2011, 09:29 PM
Goes to show that what you need is people with knowledge and motivation to get things done.