View Full Version : Study Identifies Potential Treatment for Glioma

07-13-2011, 02:15 PM
A new study identifies a potential treatment target for gliomas by focusing on an enzyme important in the production of nitric oxide in cancer stem cells.
Glioma, in all of its forms, is a primary brain tumor that routinely challenges the entire armamentarium available to the oncologist. Difficult to detect at early stages, difficult to treat once identified, it remains one of the more vexing cancers. A new study published in the July 8th 2011 issue of the journal Cell has identified a biochemical feature of glioma stem cells that may make them vulnerable to inhibitors targeting an enzyme involved in the production of nitric oxide.

Gliomas are one of the most difficult brain tumors to treat. And the worst form of glioma, glioblastoma multiforme, is commonly fatal within 18 months of diagnosis. Current approaches to treatment can include surgical debulking or removal, use of chemotherapeutic agents, radiation therapy, and combinations of all three.

Cancer Stem CellsOver the last 10 years, there has been a significant expansion in studies focused on what are believed to be tumor-specific cancer stem cells (CSCs). Numerous scientists believe that CSCs are a major contributor to both continued tumor growth and metastasis. Additionally, it appears that many of these cancer stem cells not only influence tumor growth and re-growth but are often resistant to standard anti-tumor treatment regimens. One of the key features of the new study was their focus on the biology of what they believe to be glioma stem cells.

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07-13-2011, 02:23 PM
My dad died from a brain tumor in 1982. At the time, he was in a research study at Sloan-Kettering which supposedly offered a breakthrough in how to treat these kinds of treatments. That was 29 years ago for those of you who don't want to do the math.