Jeannine
08-25-2009, 02:42 PM
Scientists improve liver stem cell engraftment with protein delivery
Researchers at INSERM (France) have engineered a chimeric protein that increases cell survival, migration and proliferation to improve stem cell engraftment. The results, which appear in the Experimental Biology and Medicine, show that TAT-Tpr-Met, a cell permeable form of the hepatocyte growth factor receptor can increase the number of hepatic stem cells integrated into the liver of the mouse. TAT-Tpr-Met is the result of the fusion of Tpr-Met, an autoactived tyrosine kinase, to the protein transduction domain from HIV-TAT that gives the potential of the whole protein to enter into cells. TAT-Tpr-Met enters into cells in just one hour, where it then remains stable and recapitulates several effects seen with the hepatocyte growth factor (HGF).
Continued....
http://www.sciencecodex.com/scientists_improve_liver_stem_cell_engraftment_wit h_protein_delivery
Researchers at INSERM (France) have engineered a chimeric protein that increases cell survival, migration and proliferation to improve stem cell engraftment. The results, which appear in the Experimental Biology and Medicine, show that TAT-Tpr-Met, a cell permeable form of the hepatocyte growth factor receptor can increase the number of hepatic stem cells integrated into the liver of the mouse. TAT-Tpr-Met is the result of the fusion of Tpr-Met, an autoactived tyrosine kinase, to the protein transduction domain from HIV-TAT that gives the potential of the whole protein to enter into cells. TAT-Tpr-Met enters into cells in just one hour, where it then remains stable and recapitulates several effects seen with the hepatocyte growth factor (HGF).
Continued....
http://www.sciencecodex.com/scientists_improve_liver_stem_cell_engraftment_wit h_protein_delivery